alley in cahors, france: 'street of the little word'

alley in cahors, france: 'street of the little word'

Bottom line: research full formulation toxicity and the endocrine system. 

The endocrine glands influence almost all of the body.  These glands and the hormones they produce directly affect energy -  including physical energy, metabolism, sexual reproduction, moods, even how tall we grow.  The endocrine system works slowly, and is vitally important.  Endocrine effects occur at very low doses.  Scientists are understanding current regulatory limits for pesticide exposure may be vastly underestimated.

The endocrine system is a target for autoimmune diseases. As the body's hormonal regulator, the endocrine system releases and then slows and/or stops the production of different hormones in response to various internal and external triggers. [1] 

Autoimmune diseases affect women significantly more than men. Their growth in the last 20 years is unprecedented.

US EPA, the WHO and the EFSA do not assess how full formulation toxicity of pesticides affect the endocrine system.  

US EPA, the WHO and the EFSA do not assess how how full formulation toxicity impacts the vulnerable endocrine systems of the developing baby, infant, child or teenager. 

Independent (university, or public domain) studies are rarely considered. (Which is why wide ranging literature reviews of all published science is required).

In order to work effectively, and lead happy healthy lives, the endocrine system needs to work well.

Scientists have evidence that many of the most commonly used pesticides are endocrine disruptors. Independent scientists agree that there is simply not enough science looking at the safety of pesticides, the cumulative effects of pesticides, the effects of pesticides by-products on the endocrine system and studies of the endocrine system with the full formula.

It is a desert of no-science.

While endocrine and autoimmune related illnesses boom, and the drug companies work to fulfil the needs of failing endocrine and immune systems.

While pesticides accumulate in drinking water, food and human biological systems. Many toxins contribute to illness, not just pesticides. We have improved diagnosis and we understand more clearly, the contribution of our genetic predisposition to particular illness.

But genetic predisposition frequently requires a 'tipping point', that stresses the body and contributes to illness.

Many scientists believe excess exposure to pesticides is frequently the tipping point that alters, or impairs the endocrine system. 

Prevention is better than cure.... but not as well funded.

The current so-called endocrine disruptor screening programs with the US EPA and the European Union constantly push out the requirements and deadlines.

As if it is not important. 

US Environmental Protection Agency

In 1996, amendments to the USA safe drinking water act authorised the EPA to screen substances. This resulted in Glyphosate being selected for the April 2009 Final List of Chemicals for Initial Tier 1 Screening. Ten years later.  In 2006 the EPA raised the residue of glyphosate permitted on wheat and cereals 6 fold. 2013 the EPA raised the residues of glyphosate on food. 

In 2013 a 'Final Second List' of chemical were released - glyphosate has disappeared [2].  Glyphosate is still on the first list? Is there a first list?  Silver tongues and smokescreens.

All the while the endocrine disruptor screening program does... what exactly? The tests modelled and adopted in the 1990's are now out of date and inadequate.

The US endocrine disruptor screening program makes lists and then rewrites the lists.

World Health Organisation

The WHO produced a marvellous 2012 paper 'State of the Science of Endocrine Disrupting Chemicals'. Yet whilst this paper discusses in depth how pesticides contribute to disrupt the endocrine system - their WHO/Food & Agriculture Organisation Toxicological Evaluations fail to include independent studies citing particular pesticides as endocrine disruptors in the critical sections which directly contribute to deciding the daily recommended allowances/exposures (ADI or RfD). These studies are simply ignored.

The WHO can produce papers like this until they are blue in the face - but the assessment process is failing us. The assessment process is failing the countries that depend on the WHO to make safe decisions as to pesticide exposure. The most recent 2016 WHO/FAO JMPR toxicological assessment of glyphosate [3] did not consider the potential of the full formulation of glyphosate based herbicides to act as an endocrine disruptor. Toxicological assessments occur ever 10-15 years. 

European Union

The EU are hard at work writing lists of potential endocrine disruptors also.  While the candidate list includes glyphosate. When the pesticide lists get honed down to a list of 146, in Annex 6, glyphosate disappears. No glyphosate on this list either:  List of 146 substances with endocrine disruption classifications prepared in the Expert meeting. 

In 2016, Pan Europe won a legal case at the European Court of Justice against the EU Commission (DG Trade), for refusing to provide access to documents with information on endocrine disrupting chemicals (EDCs).

The 3 agencies, the WHO, US EPA and EU prioritise corporate science via guidelines and protocols that restrict enquiry into subtle low dose full formulation exposures - they do not appear to conduct assessment that takes into account 21st century scientific understanding, rather they restrict themselves to single active ingredient studies at relatively high doses.

What is the endocrine system?

The endocrine glands include the adrenal glands, pineal gland, hypothalamus, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland and gastrointestinal tract.

Many other organs have secondary endocrine functions, such as the liver, kidney, gonads and heart. 

 

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References:
[1] Womensinternational.com. Autoimmune disease and the endocrine system. 

[2] Endocrine Disruptor Screening Program; Final Second List of Chemicals and Substances for Tier 1 Screening. Final second list of 109 chemicals identified for Tier 1 screening under the Endocrine Disruptor Screening Program (EDSP). May 29 2013.  EPA–HQ–OPPT–2009–0477; FRL–9375-8

[3]  Pesticide residues in food - 2016 evaluations. Part II - Toxicological. World Health Organization, 2017 Page 89 onwards  

2016: Epigenetic Effects of Endocrine Disrupting Chemicals. Shahidehnia, M.  J Environ Anal Toxicol 2016, 6:4 http://dx.doi.org/10.4172/2161-0525.1000381

Gore AC et al 2015.  Endocrine Society's Second Scientific Statement. DOI:10.1210/er.2015-1093

Goodson et al 2015. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures

Colborn T, vom Saal FS, Soto AM (October 1993). "Developmental effects of endocrine-disrupting chemicals in wildlife and humans". Environ. Health Perspect. 101 (5): 37884.  doi:10.2307/3431890