These studies are directly supplied to the US EPA, WHO & EU by corporations.  Please note:

  1. Dose response relationship may not be consistent when the endocrine system is affected.

  2. The safe level is often declared at the same level problems occur.  These are often dismissed. 

  3. Who establishes statistical/historical significance?

  4. Public sector endocrinologists/immunologists are rarely, if ever, consulted.

The only study that refers to the thyroid held publicly with the US EPA. It also establishes the ADI for Europe: “The following findings were observed in the high-dose groups when compared with the concurrent controls: (1) increased incidence of thyroid C-cell carcinomas in females; and (2) increased incidence of interstitial cell (Leydig cell) testicular tumors. However, the Agency concluded that these neoplasms were not treatment-related and glyphosate was not considered to be carcinogenic in this study because the incidence of thyroid carcinomas was not statistically significant and the incidence of testicular tumors was within the historical incidence. “
— Lankas, G.R.; Hogan, G.K. (1981) A Lifetime Feeding Study of Glyphosate. Monsanto
 
The proportion of fetuses with minor skeletal defects was statistically significantly increased at the lowest (100mg/kg) and highest doses (300mg/kg),...Consideration of the specific defects revealed a statistically significantly increased incidence of fetuses with partially ossified transverse processes of the seventh vertebra in the group receiving the highest dose (5.6%, compared with 0.7% in controls), unossified transverse processes of the seventh lumbar vertebra (9.7%, compared with 2.8% in controls) or partially ossified sixth sternebra (11.1%, compared with 2.8% in controls)....NOAEL for maternal toxicity was 100 mg/kg per day on the basis of clinical signs and reduced food consumption and body-weight gain at 175mg/kg bw per day and greater. The NOAEL for developmental toxicity was 175 mg/kg per day on the basis of reduced fetal weight and reduced ossification at 300mg/kg bw per day
— Moxon, M.E. (1996b) :Glyphosate acid: developmental toxicity study in the rabbit. Syngenta
 
This Cheminova study establishes the ADI for glyphosate for the WHO: “The only remarkable histopathological finding attributed to administration of glyphosate was a dose-related increase in the number of animals exhibiting cellular alteration of the parotid and mandibular (submaxillary) salivary glands at the highest dose and at both intermediate doses (intermediate doses are 300 and 100 mg/kg bw/day).......Thus, the NOAEL was 100mg/kg bw per day”
— Atkinson, C., Strutt, A.V., Henderson, W., Finch, J. & Hudson, P. (1993b) Glyphosate: 104 week combined chronic feeding/oncogenicity study
 
30 female 30 male fed for 2 successive generations and up to weaning of third generation at levels of 0, 100, 1000, and 10,000ppm. First parental animals treated 10 weeks before mating. Only one litter each generation. Results: Respiratory affections. One dam died of dystocia in the low dose group. One high and low dose female died during the lactation period. (these deaths could not be attributable to treatment). Mean litter size reduced in the F1 generation least at the low and mid dose level. However there was no clear dose response and the finding was not confirmed in the F2 generation. Conclusion: NOEL at 10,000ppm considered for both parental and reproductive toxicity
— Suresh, T.P. (1993) [3]: Two generation reproduction study in Wistar rats. Rallis Ltd.
Slight growth retardation during part of the study was noted in the high-dose males. The incidence of interstitial cell tumours in testes showed a statistically significant increase (incidences: 0/50, 3/50, 1/50 and 6/50; historical control range: 3–7%) (Bio/Dynamics Inc., 1981a). This finding, in itself constituting evidence of a carcinogenic effect in
rats, should be judged in light of the absence of an effect at much higher dose levels in the more recent 2-year study in rats (see below). This is also valid for the slight growth retardation. The NOAEL was 32 mg/kg of body weight per day, the highest dose tested.
— The WHO test establishing the global ADI shows effects at the highest dose tested, but then declares the safe level, the very same level showing damage. Bio/Dynamics Inc. (1981a) A lifetime feeding study of glyphosate (Roundup technical) in rats. Unpublished report prepared by Bio/Dynamics Inc., Division of Biology and Safety Evaluation, East Millstone, NJ. Submitted to WHO by Monsanto Ltd. (Project No. 410/77; BDN-77-416).
 
Owing to the lack of a dose–response relationship, the lack of statistical significance and the fact that the incidences recorded in this study fell within the historical ranges for controls, these changes are not considered to be caused by administration of glyphosate.
— Atkinson, C., Martin, T., Hudson, P. & Robb, D. (1993a) Glyphosate: 104 week dietary carcinogenicity study in mice. Cheminova
 
Thyroid weights were significantly increased at termination in males
(absolute, 22%; relative, 26%) and females (absolute, 24%; relative, 26%) at 15 mg/kg bw per day and
in males (absolute, 26%; relative, 29%) at 45 mg/kg bw per day; females at 45 mg/kg bw per day also
showed increases in absolute (2%) and relative (16%) thyroid weights, but the increases were not
statistically significant.... No treatment-related neoplastic lesions were seen at any dose. There was an increase in the incidence of brain astrocytomas in male rats, with l/50 (2%), 0/50,0/50,2J48 (4%), and 6/50 (12%) seen in the controls and in rats at 1,5, 15, and 45 mg/kg bw per day, respectively. Although there was a positive trend @ = 0.002), a pairwise test did not show statistical significance (p = 0.055) when the incidence at the high dose (6/60) was compared with that of the controls (l/50). The brain astrocytomas are not attributable to treatment because they did not occur earlier in treated rats than in controls (no decreased latency).
— Serota 1986